The course mainly aims to:

• Provide an updated scenario of the functional molecular interactions that can be impaired during cryopreservation (also altering epigenetics). The course will focus also on the protein/protein and protein/lipid interactions that can give a functional modulation of gametes.

• Describe the gametes biology at physiological and low temperatures.

• Describe the applications of gametes cryoconservation techniques.

• To introduce the fundamentals of computational modeling in cryobiology.