To identifying the lipidomic profiling of cell membranes in: healthy domestic species (cat, dog, and horse) as control, by using lipidomic techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy (NCSR, Lipinutragen) and in selected chronic pathological conditions (i.e. feline diabetes mellitus, canine Inflammatory Bowel Disease, equine osteoarthritis);

Correlation between fatty acid membrane composition and dietary;

To determine the effect of dietary and exercising on experimental models on lipidomic membrane profile through sirtuin-mediated pathways (ESR 10);

To studying the relationship between spermatozoa fatty acid membrane composition in domestic species (cat, dog, and horse) by interacting with ESR3 and ESR12.

ESR 9

Evaluation of the intestinal microbiome in obese pet owners and their obese pets

Internal Tutor

Fulvio Marsilio

External academic institution

Texas A&M University

Nuben Nutrizione e benessere

Tutor

Jan Suchodolski

Non-academic institution

Synbiotec S.r.l.

Supervisor

Alberto Cresci

Supervisor

Paolo De Cristofaro

ESR:

Sandra Bermudez Sanchez

Objectives, methods and topic interactions:

To define the profile of gut and intestinal microbiome in obese animals (dogs or cats), obese diabetic animals (dogs or cats), obese non diabetic human being and obese diabetic human being living in the same household (nuben)

To determine the influence of the same diet;

To assess if the intestinal microbiome is shared among individuals and pets living in the same household (in collaboration with ESR7 and Synbiotec);

To provide data regarding the fecal microbiome as a potential non-invasive biomarker for early diagnosis of disease (TAMU)

To evaluate specific microorganisms that are part of the intestinal microbiome as they relate to specific health conditions (i.e., diabetes mellitus or obesity).

ESR 10

The SIRT1 activator resveratrol in the treatment of obesity and diabetes

Internal Tutor

Fernanda Amicarelli

Stefano Falone

External academic institution

Temple University

Tutor

Antonio Giordano

Non-academic institution

Dompé farmaceutici s.p.a.

Supervisor

Marcello Allegretti

ESRs

Maihemuti Mijiti

Objectives, methods and topic interactions:

To understanding of the relationship of genetic background with diet and life style.

To understanding of the phases of the mechanisms underlying insulin-related disturbances and Type2 diabetes onset.

To understanding of the biochemical assays for energy metabolism, protein expression and gene profiling, as well as epigenetic regulation (TU).

To understanding of the positive or negative effects of dietary supplementation and/or exercise regimen in relation to obesity-induced dismetabolism. It will be especially investigated Resveratrol, which acts as an activator of sirtuin 1 (SIRT1), a molecular target for the treatment of metabolic disorders, such as obesity (Dompé).

Interaction with ESR 4 and ESR3, by assessing whether specific dietary and exercising experimental models could be used to attenuate or revert common animal diseases and dismetabolism through sirtuin-mediated pathways .

Rep-Eat - H2020-MSCA-COFUND-2015

University of Teramo - Via Renato Balzarini 1 - 64100 - Teramo (TE) - Italy

repeat@unite.it - Private Area

REP_EAT MSCA Co-funding of regional, national and international programmes (COFUND) HORIZON 2020” – Grant Agreement N. 713714.CUP: C47B16000360007

University of Teramo

Abruzzo Region