EAT-FOOD

Objectives: To study the cell membrane lipid profile and the SIRTUIN expression either in physiological or in pathological conditions, and its connection with intestinal microbiome

ESR 4: The lipidomic analysis in the veterinary field: study of the cell membranes lipid profile in physiological and pathological conditions

Andrea Boari, Alessandro Gramenzi - University of Teramo

 

ESR9: Evaluation of the intestinal microbiome in obese pet owners and their obese pets

Fulvio Marsilio, Alessandro Gramenzi - University of Teramo

Alessandro Gramenzi, University of Teramo

 

ESR10: The SIRT1 activator resveratrol in the treatment of obesity and diabetes

Fernanda Amicarelli, Stefano Falone - University of L'Aquila

 

 
 
 
 
 
 
 

The lipidomic analysis in the veterinary field: study of the cell membranes lipid profile in physiological and pathological conditions

ERS 04

Internal tutor

Andrea Boari

Alessandro Gramenzi

 

External academic institution

National Center of Scientific Research "Demokritos"

 

 

Tutor

Chryssostomos Chatgilialoglu

 

Non-academic institution

Lipinutragen S.R.L.

 

Supervisor

Carla Ferreri

 

Objectives, methods and topic interactions:

  • To identifying the lipidomic profiling of cell membranes in: healthy domestic species (cat, dog, and horse) as control, by using lipidomic techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy (NCSR, Lipinutragen) and in selected chronic pathological conditions (i.e. feline diabetes mellitus, canine Inflammatory Bowel Disease, equine osteoarthritis);
  • Correlation between fatty acid membrane composition and dietary;
  • To determine the effect of dietary and exercising on experimental models on lipidomic membrane profile through sirtuin-mediated pathways (ESR 10);
  • To studying the relationship between spermatozoa fatty acid membrane composition in domestic species (cat, dog, and horse) by interacting with ESR3 and ESR12.
 

Evaluation of the intestinal microbiome in obese pet owners and their obese pets

ERS 09

Internal Tutor

Fulvio Marsilio

Alessandro Gramenzi 

 

External academic institution

Texas A&M University

Nuben Nutrizione e benessere

 

Tutor

Jan Suchodolski

 

Non-academic institution

Synbiotec S.r.l.

 

Supervisor

Alberto Cresci

 

Supervisor

Paolo De Cristofaro

 

Objectives, methods and topic interactions:

  • To define the profile of gut and intestinal microbiome in obese animals (dogs or cats), obese diabetic animals (dogs or cats), obese non diabetic human being and obese diabetic human being living in the same household (nuben)
  • To determine the influence of the same diet;
  • To assess if the intestinal microbiome is shared among individuals and pets living in the same household (in collaboration with ESR7 and Synbiotec);
  • To provide data regarding the fecal microbiome as a potential non-invasive biomarker for early diagnosis of disease (TAMU)
  • To evaluate specific microorganisms that are part of the intestinal microbiome as they relate to specific health conditions (i.e., diabetes mellitus or obesity).
 

The SIRT1 activator resveratrol in the treatment of obesity and diabetes

ERS 10

Internal Tutor

Fernanda Amicarelli

Stefano Falone

 

External academic institution

Temple University

 

Tutor

Antonio Giordano

 

Non-academic institution

Dompé farmaceutici s.p.a.

 

Supervisor

Marcello Allegretti

 

Objectives, methods and topic interactions:

  • To understanding of the relationship of genetic background with diet and life style.
  • To understanding of the phases of the mechanisms underlying insulin-related disturbances and Type2 diabetes onset.
  • To understanding of the biochemical assays for energy metabolism, protein expression and gene profiling, as well as epigenetic regulation (TU).
  • To understanding of the positive or negative effects of dietary supplementation and/or exercise regimen in relation to obesity-induced dismetabolism. It will be especially investigated Resveratrol, which acts as an activator of sirtuin 1 (SIRT1), a molecular target for the treatment of metabolic disorders, such as obesity (Dompé).
  • Interaction with ESR 4 and ESR3, by assessing whether specific dietary and exercising experimental models could be used to attenuate or revert common animal diseases and dismetabolism through sirtuin-mediated pathways .
 

 

Rep-Eat - H2020-MSCA-COFUND-2015

University of Teramo - Via Renato Balzarini 1 - 64100 - Teramo (TE) - Italy

repeat@unite.it  -  Private Area

 
Flag UE

This project has received funding from the European Union’s Horizon 2020 

research and innovation programme under 

the Marie Skłodowska-Curie grant agreement No 713714

 

 

Co-funding institutions